By Adam Spjute, MD What is Complex Regional Pain Syndrome? Complex regional pain syndrome is a syndrome that’s caused from nerves that continue to fire, particularly in extremities (which means the furthest point in a limb) that causes swelling, discoloration and decreased movement when there’s no obvious pathology. There are several components that are necessary for it to fall under Complex Regional Pain Syndrome. You need pain, discoloration, swelling, and generally there’s decreased mobility. How Long Has Complex Regional Pain Syndrome Been Around? The first recorded instance of Complex Regional Pain Syndrome was in the Civil War. There were a lot of scholarly papers and